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独立后第16篇 -丹参酮衍生物的构效关系研究 TL

文章来源:  |  发布时间:2018-06-19  |  作者:  |  浏览次数:  |  【打印】 【关闭

 

Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives

 Tetrahedron Lett. 2018, 59, 46-48.

ab stra ct
Tanshinones were used as starting material to synthesize a small library of nitrogen heterocyclic deriva-
tives featured with oxazole, imidazole, and pyrazine ring between C-11/C-12 by simple methods. Except
for salviamine A and isosalviamine A, 22 new derivatives were synthesized. Their structures were con-
firmed by spectroscopic analysis. Moreover, 11 derivatives exhibited moderate cytotoxic activities
against five human cancer lines in vitro.

 

 

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