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独立后第18篇 -鼠尾草酸的转化与构效关系研究 TL

文章来源:  |  发布时间:2018-06-19  |  作者:  |  浏览次数:  |  【打印】 【关闭

 

Semisynthesis of miltirone, 1,2-dehydromiltirone, saligerone from carnosic acid and cytotoxities of their derivatives

 Tetrahedron Lett. 2018, 59, 2607-2609.

 

 

ab stra ct
Miltirone, 1,2-dehydromiltirone, saligerone have been synthesized form carnosic acid. Among them, one step transformation of carnosic acid into miltirone was realized when decarboxylation/aromatization was promoted by Lewis acid. Moreover, 4 derivatives exhibited potent cytotoxic activities against three human cancer lines in vitro.

 

 

 

 

 

 

 

 

 

 

 

https://www.sciencedirect.com/science/article/pii/S0040403918306981

 

 

 


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