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独立后第19篇 -(-)-Akaol的不对称全合成 Org.Chem.Front.

文章来源:  |  发布时间:2018-06-19  |  作者:  |  浏览次数:  |  【打印】 【关闭

 

Total synthesis of (?)-akaol A via a conformational constraint strategy

 

 Org. Chem. Front., 2018,5, 1886-1889;  IF  4.955

 

Ab stra ct


The enantioselective total synthesis of (?)-akaol A has been achieved. The key reaction features a well-designed Friedel–Crafts cyclization, which ensured a cis-fused B/C ring through a conformational constraint strategy. In marked control to trans-fused B/C ring cyclization promoted by a routine acid, the complete cis selective formation of the B/C ring was realized for the first time. Bistri-fluoromethane-sulfonimide promoted the key cyclization effectively. Our synthesis involves 13 steps from known aldehyde 2 and proceeds in 10.7% overall yield.

 

 

 

http://pubs.rsc.org/en/content/articlelanding/2018/qo/c8qo00375k#!divAbstract

 

 

 


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