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独立后第21篇 -罗列酮衍生物的构效关系研究 NPB

文章来源:  |  发布时间:2018-06-19  |  作者:  |  浏览次数:  |  【打印】 【关闭

 

Synthesis and Cytotoxicities of Royleanone Derivatives

 Nat. Prod. Bioprospect. 2018

 

Ab stra ct


Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11–C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.

 

 

https://link.springer.com/article/10.1007/s13659-018-0173-y

 

 

 


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