天然产物不对称全合成专题组
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研究成果
Publications 2021- 33. Bing-Lu Wu, Jian-Neng Yao, Xiang-Xi Long, Zong-Qin Tan, Xiao Liang, Li Feng, Kun Wei, Yu-Rong Yang* “Enantioselective Total Synthesis of (−)-Daphenylline” J. Am. Chem. Soc. 2024, 146, 1262-1268. 32. Peng-Zhen Sheng, Zhi-Bin Ni, Lu-Lu Li, Kun Wei, Hongbin Zhang, Yu-Rong Yang* “Enantioselective Total Syntheses of the Cephalotaxus Alkaloids (−)-Fortuneicyclidins A and B and (−)-Cephalotine B” Org. Lett. 2023, 25, 7464−7469. 31. Peng-Zhen Sheng, Lu-Lu Li, Zhi-Bin Ni, Kun Wei,* Yu-Rong Yang* “Enantioselective Total Synthesis of the Cephalotaxus Alkaloid (−)-Cephalotine A” Org. Lett. 2023, 25, 7459−7463. 30. Lei Li,§ Hua-Fei Yang,§ Qian-Hui Ding, Kun Wei*, Yu-Rong Yang* “Total Syntheses of Cinchona Alkaloids via Photoredox-Catalyzed Deoxygenative Arylation” Org. Lett. 2023, 25, 4586-4591. 29. Peng-Zhen Sheng,§ Lu-Lu Li,§ Hongbin Zhang, Kun Wei*, Yu-Rong Yang* “Enantioselective total syntheses of (−)-cephalotaxine and (−)-amathaspiramide F through a key Ir/Cu dual catalysis” Org. Chem. Front., 2023, 10, 2532-2537. 28. Tian-Yuan Zhang, Lu-Yue Zhang, Xiao Liang, Kun Wei*, and Yu-Rong Yang* “Catalytic, Asymmetric Total Synthesis of (+)-α‑, (+)-β‑, (+)-γ‑, and (−)-δ-Lycorane” Org. Lett. 2022, 24, 2905−2909. 27. Yi Deng,§ Xiao Liang,§ Kun Wei,§ Yu-Rong Yang* “Ir-Catalyzed Asymmetric Total Syntheses of Bisdehydrotuberostemonine D, Putative Bisdehydrotuberostemonine E and Structural Revision of the Latter” J. Am. Chem. Soc. 2021, 143, 20622-20627. 26. Lei Li, Li Shi, Kun Wei*, Yu-Rong Yang* “Asymmetric Total Synthesis of (+)-Quinocarcinamide” Org. Lett. 2021, 23, 7972-7975. 25. Xiao Liang,§ Lei Li,§ Kun Wei, Yu-Rong Yang* “Gram-Scale, Seven-Step Total Synthesis of (−)-Colchicine” Org. Lett. 2021, 23, 2731-2735. 24. Tian-Yuan Zhang,§ Yi Deng,§ Kun Wei, Yu-Rong Yang* “Enantioselective Iridium-Catalyzed Allylic Alkylation of RacemicBranched Alkyl-Substituted Allylic Acetates with Malonates” Org. Lett. 2021, 23, 1086-1089. 23. Yu Zheng, Hong-Dou Yang, Kun Wei,* Yu-Rong Yang* “Synthetic Studies toward Parvistemoline Using Asymmetric Ir/ Amine-Catalyzed Allylation” J. Org. Chem. 2021, 86, 6025-6029. Publications 2020-2016: 22. Yu Zheng, Xue-Dan Li, Peng-Zhen Sheng, Hong-Dou Yang, Kun Wei, Yu-Rong Yang* “Asymmetric Total Syntheses of (−)-Fennebricin A, (−)-Renieramycin J, (−)-Renieramycin G, (−)-Renieramycin M, and (−)-Jorunnamycin A via C−H Activation” Org. Lett. 2020, 22, 4489−4493. 21. Jian-Neng Yao, Xiao Liang, Kun Wei, Yu-Rong Yang* “Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine” Org. Lett. 2019, 21, 8485-8487. 20. Chun-Yan Meng, Xiao Liang, Hongbin Zhang, Kun Wei*, Yu-Rong Yang* “Stereocontrolled concise synthesis of (±)-halosaline through intramolecular C-H amination” Tetrahedron Letters 2019, 60, 1781–1783. 19. Bei-Bei Yue, Yi Deng, Yu Zheng, Kun Wei*, Yu-Rong Yang* “Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides andEnecarbamates” Org. Lett. 2019, 21, 2449-2452. 18. Chun-Yan Meng, Xiao Liang, Kun Wei*, Yu-Rong Yang* “Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic AllylicAlcohols with Malonates” Org. Lett. 2019, 21, 840-843. 17. Yu Zheng,Bei-Bei Yue, Kun Wei, Yu-Rong Yang* “Iridium-Catalyzed Enantioselective Allyl–Allyl Cross-Coupling of Racemic Allylic Alcohols with Allylboronates” Org. Lett. 2018, 20, 8035–8038. 16. Xiao Liang, Tian-Yuan Zhang, Chun-Yan Meng, Xue-Dan Li, Kun Wei, Yu-Rong Yang* “Total Synthesis of (−)-Actinophyllic Acid Enabled by a Key Dual Ir/Amine-Catalyzed Allylation” Org. Lett. 2018, 20, 4575-4578. 15. Yu Zheng,Bei-Bei Yue, Kun Wei, Yu-Rong Yang* “Short Synthesis of the Monoterpene Indole Alkaloid (±)-Arbornamine” J. Org. Chem. 2018, 83, 4867-4870. 14. Xiao Liang, Tian-Yuan Zhang, Xue-Yi Zeng, Yu Zheng, Kun Wei, Yu-Rong Yang* “Ir-Catalyzed Asymmetric Total Synthesis of (-)-Communesin F” J. Am. Chem. Soc. 2017, 139, 3364-3367. 13. Yu Zheng, Kun Wei,* Yu-Rong Yang* “Total Synthesis of (-)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step” Org. Lett. 2017, 19, 6460-6462. 12. Xiao Liang, Shi-Zhi Jiang, Kun Wei, Yu-Rong Yang* “Enantioselective Total Synthesis of (-)-Alstoscholarisine A” J. Am. Chem. Soc. 2016, 138, 2560-2562. 11. Shi-Zhi Jiang, Xue-Yi Zeng, Xiao Liang, Ting Lei, Kun Wei, Yu-Rong Yang* “Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-Aspidophylline A” Angew. Chem. Int. Ed. 2016, 55, 4044-4048. Publications 2015-2010: 10. Xiao Liang, Kun Wei*, Yu-Rong Yang* “Iridium-Catalyzed Enantioselective Allylation of Silyl Enol Ethers Derived from Ketones and a,b-Unsaturated Ketones” Chem. Commun. 2015, 51, 17471-17474. 9. Ting Lei, Hongbin Zhang*, Yu-Rong Yang* “Iridium-Catalyzed Enantioselective Synthesis of (-)- and (+)-Aurantioclavine” Tetrahedron Lett. 2015, 56, 5933-5936. 8. Shi-Zhi Jiang, Ting Lei, Kun Wei, Yu-Rong Yang* “Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof” Org. Lett. 2014, 16, 5612-5615. 7. Liao-Bin Dong, Ya-Nan Wu, Shi-Zhi Jiang, Xing-De Wu, Juan He, Yu-Rong Yang* Qi-Shi Zhao* “Isolation and Complete Structural Assignment of Lycopodium Alkaloid Cernupalhine A: Theoretical Prediction and Total Synthesis Validation” Org. Lett. 2014, 16, 2700-2703. 6. Jiu-Zhong Huang, Xiao-Ke Jie, Kun Wei, Hongbin Zhang, Min-Cai Wang, Yu-Rong Yang* “Formal Synthesis of Aspidospermine via the Intramolecular Cascade Transannular Cyclization” Synlett. 2013, 24, 1303-1306. 5. Tao Xu, Xiu-Li Luo, Yu-Rong Yang* “Asymmetric Total Synthesis of Lycopodium Alkaloid (+)-Lycopladine A” Tetrahedron Lett. 2013, 54, 2858-2860. 4. Tao Xu, Shi-Zhi Jiang, Huai-Rong Luo, Yu-Rong Yang*. “One-step Synthesis of Lycopodium Alkaloid (-)-Huperzine W via Suzuki-Miyaura Coupling” Natural Products and Bioprospecting 2012, 2, 255. 3. Yu-Rong Yang*, Liang Shen, Jiu-Zhong Huang, Tao Xu, Kun Wei. “Application of the Helquist Annulation in Lycopodium Alkaloids Synthesis: Unified Total Syntheses of (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Lycoflexine” J. Org. Chem. 2011, 76, 3684-3690. 2. Yu-Rong Yang*, Zeng-Wei Lai, Liang Shen, Jiu-Zhong Huang, Xing-De Wu, Jun-Lin Yin, Kun Wei “Total Synthesis of (-)-8-Deoxyserratinine via an Efficient Helquist Annulation and Double N-Alkylation Reaction” Org. Lett. 2010, 12, 3430-3433. 1. Yu-Rong Yang*, Liang Shen, Kun Wei, Qin-Shi Zhao “Cyclization Approaching to (−)-Lycojapodine A: Synthesis of Two Unnatural Alkaloids” J. Org. Chem. 2010, 75, 1317-1320.
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